Module 1: Introduction to Aromatic Compounds
Aromaticity:
Definition and criteria for aromaticity (Hückel's rule)
Stability of aromatic compounds
Examples of aromatic compounds (benzene, naphthalene, anthracene)
Nomenclature of Aromatic Compounds:
IUPAC nomenclature
Common names
Naming substituted benzenes and polycyclic aromatic hydrocarbons
Module 2: Reactions of Aromatic Compounds
Electrophilic Aromatic Substitution (EAS):
Mechanism of EAS reactions
Common electrophilic reagents (halogenation, nitration, sulfonation, Friedel-Crafts alkylation and acylation)
Directing effects of substituents (ortho-para directors and meta directors)
Nucleophilic Aromatic Substitution (NAS):
Mechanism of NAS reactions (addition-elimination and elimination-addition)
Reactivity of aryl halides
The benzyne mechanism
Module 3: Phenols
Structure and Properties of Phenols:
Acidity of phenols
Effect of substituents on acidity
Hydrogen bonding in phenols
Reactions of Phenols:
Electrophilic aromatic substitution (EAS) reactions of phenols
Reactions with bases (formation of phenoxides)
Oxidation of phenols
Esterification of phenols
Module 4: Applications of Phenols and Aromatic Compounds
Industrial applications:
Dyes and pigments
Pharmaceuticals
Polymers
Pesticides
Biological importance:
Aromatic amino acids
Nucleic acids
Vitamins
Content Outline
Module 1: Introduction to Aromatic Compounds
Aromaticity:
Delocalization of pi electrons
Hückel's rule (4n+2 pi electrons)
Stability of aromatic compounds compared to non-aromatic and anti-aromatic compounds
Examples of aromatic compounds (benzene, naphthalene, anthracene)
Nomenclature of Aromatic Compounds:
IUPAC nomenclature for benzene derivatives
Common names (toluene, phenol, aniline)
Naming disubstituted and polysubstituted benzenes
Naming fused ring systems (naphthalene, anthracene)
Module 2: Reactions of Aromatic Compounds
Electrophilic Aromatic Substitution (EAS):
Mechanism of EAS reactions (formation of sigma complex, regeneration of aromaticity)
Halogenation (chlorination, bromination)
Nitration
Sulfonation
Friedel-Crafts alkylation and acylation
Directing effects of substituents (ortho-para directors and meta directors)
Nucleophilic Aromatic Substitution (NAS):
Mechanism of NAS reactions (addition-elimination and elimination-addition)
Reactivity of aryl halides (halogen leaving group ability)
The benzyne mechanism
Module 3: Phenols
Structure and Properties of Phenols:
Acidity of phenols compared to alcohols
Effect of substituents on acidity (electron-donating and electron-withdrawing groups)
Hydrogen bonding in phenols
Reactions of Phenols:
Electrophilic aromatic substitution (EAS) reactions (ortho-para directing)
Reactions with bases (formation of phenoxides)
Oxidation of phenols (formation of quinones)
Esterification of phenols (formation of phenyl esters)
Module 4: Applications of Phenols and Aromatic Compounds
Industrial applications:
Dyes and pigments (aniline dyes)
Pharmaceuticals (aspirin, paracetamol)
Polymers (phenol-formaldehyde resins)
Pesticides (DDT)
Biological importance:
Aromatic amino acids (phenylalanine, tyrosine, tryptophan)
Nucleic acids (aromatic bases in DNA and RNA)
Vitamins (vitamin K)
Teaching Strategies:
Lectures: Introduce new concepts, provide explanations, and discuss examples.
Problem-solving sessions: Practice problems to reinforce understanding and develop problem-solving skills.
Laboratory experiments: Conduct experiments to illustrate key concepts and reactions.
Group discussions: Encourage student participation and critical thinking.
Visual aids: Use diagrams, models, and presentations to enhance understanding.
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